Signaling between pancreatic β cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation

Chronic low-grade inflammation in the pancreatic islets is observed in individuals with type 2 diabetes, and macrophage levels are elevated in the islets of these individuals. However, the molecular mechanisms underlying the interactions between the pancreatic β cells and macrophages and their invol...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Inoue, Hideaki, Shirakawa, Jun, Togashi, Yu, Tajima, Kazuki, Okuyama, Tomoko, Kyohara, Mayu, Tanaka, Yui, Orime, Kazuki, Saisho, Yoshifumi, Yamada, Taketo, Shibue, Kimitaka, Kulkarni, Rohit N., Terauchi, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912464/
https://ncbi.nlm.nih.gov/pubmed/29496993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809228
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