DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid

BACKGROUND: Diabetes therapy that not only lowers glucose levels but also lengthens life spans is required. We previously demonstrated that DPP-4 inhibition ameliorated β cell apoptosis and adipose tissue inflammation in β cell-specific glucokinase haploinsufficient mice fed a diet containing a comb...

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Bibliographic Details
Published in:Diabetol Metab Syndr
Main Authors: Shirakawa, Jun, Okuyama, Tomoko, Kyohara, Mayu, Yoshida, Eiko, Togashi, Yu, Tajima, Kazuki, Yamazaki, Shunsuke, Kaji, Mitsuyo, Koganei, Megumi, Sasaki, Hajime, Terauchi, Yasuo
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774120/
https://ncbi.nlm.nih.gov/pubmed/26937254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13098-016-0138-4
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