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Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Monoclonal antibodies (mAbs) are powerful tools useful for both fundamental research and in biomedicine. Their high specificity is indispensable when the antibody needs to distinguish between highly related structures (e.g., a normal protein and a mutated version thereof). The current way of generat...

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Bibliografski detalji
Izdano u:J Vis Exp
Glavni autori: Devilder, Marie-Claire, Moyon, Mélinda, Saulquin, Xavier, Gautreau-Rolland, Laetitia
Format: Artigo
Jezik:Inglês
Izdano: MyJove Corporation 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912359/
https://ncbi.nlm.nih.gov/pubmed/29443062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/56508
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