Imaging Human Pancreatic Cancer Xenografts by Targeting Mutant KRAS2 mRNA with [(111)In]DOTA(n)-Poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) Nanoparticles

95% of patients with ductal pancreatic cancer carry 12th codon activating mutations in their KRAS2 oncogenes. Early whole body imaging of mutant KRAS2 mRNA activation in pancreatic cancer would contribute to disease management. Scintigraphic hybridization probes to visualize gene activity in vivo co...

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Enregistré dans:
Détails bibliographiques
Publié dans:Bioconjug Chem
Auteurs principaux: Amirkhanov, Nariman V., Zhang, Kaijun, Aruva, Mohan R., Thakur, Mathew L., Wickstrom, Eric
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912162/
https://ncbi.nlm.nih.gov/pubmed/20232877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900523c
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