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Imaging Human Pancreatic Cancer Xenografts by Targeting Mutant KRAS2 mRNA with [(111)In]DOTA(n)-Poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) Nanoparticles
95% of patients with ductal pancreatic cancer carry 12th codon activating mutations in their KRAS2 oncogenes. Early whole body imaging of mutant KRAS2 mRNA activation in pancreatic cancer would contribute to disease management. Scintigraphic hybridization probes to visualize gene activity in vivo co...
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| Foilsithe in: | Bioconjug Chem |
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| Main Authors: | , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2010
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5912162/ https://ncbi.nlm.nih.gov/pubmed/20232877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900523c |
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