Imaging Human Pancreatic Cancer Xenografts by Targeting Mutant KRAS2 mRNA with [(111)In]DOTA(n)-Poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) Nanoparticles

95% of patients with ductal pancreatic cancer carry 12th codon activating mutations in their KRAS2 oncogenes. Early whole body imaging of mutant KRAS2 mRNA activation in pancreatic cancer would contribute to disease management. Scintigraphic hybridization probes to visualize gene activity in vivo co...

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Detalles Bibliográficos
Publicado en:Bioconjug Chem
Main Authors: Amirkhanov, Nariman V., Zhang, Kaijun, Aruva, Mohan R., Thakur, Mathew L., Wickstrom, Eric
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912162/
https://ncbi.nlm.nih.gov/pubmed/20232877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900523c
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