T cell receptor-regulated TGFβ type I receptor expression determines T cell quiescence and activation

It is unclear how quiescence is enforced in naïve T cells, but activation by foreign antigens and self-antigens is allowed, despite the presence of inhibitory signals. We showed that active transforming growth factor-beta (TGFβ) signaling was present in naïve T cells and T cell receptor (TCR) engage...

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Vydáno v:Immunity
Hlavní autoři: Tu, Eric, Chia, Cheryl P.Z., Chen, Weiwei, Zhang, Dunfang, Park, Sang A, Jin, Wenwen, Wang, Dandan, Alegre, Maria-Luisa, Zhang, Ying E., Sun, Lingyun, Chen, WanJun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911925/
https://ncbi.nlm.nih.gov/pubmed/29669252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.03.025
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