Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice

Congenital amegakaryocytic thrombocytopenia (CAMT) is a disorder caused by c-MPL mutations that impair thrombopoietin (TPO) signalling, resulting in a near-absence of megakaryocytes (MKs). While this phenotype is consistent in adults, neonates with CAMT can present with severe thrombocytopenia despi...

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Bibliografiska uppgifter
I publikationen:Thromb Haemost
Huvudupphovsmän: Lorenz, Viola, Ramsey, Haley, Liu, Zhi-Jian, Italiano, Joseph, Hoffmeister, Karin, Bihorel, Sihem, Mager, Donald, Hu, Zhongbo, Slayton, William B., Kile, Benjamin T., Sola-Visner, Martha, Ferrer-Marin, Francisca
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911346/
https://ncbi.nlm.nih.gov/pubmed/29212120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH17-06-0433
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