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Characterization of murine antibody responses to vaccinia virus envelope protein A14 reveals an immunodominant antigen lacking of effective neutralization targets

Vaccinia virus (VACV) A14 is a major envelope protein and a dominant antibody target in the smallpox vaccine. However, the role of anti-A14 antibodies in immunity against orthopoxviruses is unclear. Here, we characterized 22 A14 monoclonal antibodies (mAb) from two mice immunized with VACV. Epitope...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Meng, Xiangzhi, Kaever, Thomas, Yan, Bo, Traktman, Paula, Zajonc, Dirk M., Peters, Bjoern, Crotty, Shane, Xiang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911218/
https://ncbi.nlm.nih.gov/pubmed/29558682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2018.03.005
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