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The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice

Improved delivery of adeno-associated virus (AAV) vectors to the CNS will greatly enhance their clinical utility. Selection of AAV9 variants in a mouse model led to the isolation of a capsid called PHP.B, which resulted in remarkable transduction of the CNS following intravenous infusion. However, w...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Hordeaux, Juliette, Wang, Qiang, Katz, Nathan, Buza, Elizabeth L., Bell, Peter, Wilson, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911151/
https://ncbi.nlm.nih.gov/pubmed/29428298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.01.018
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