Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells

Reactive oxygen species formed within the mammalian cell can produce 8-oxo-7,8-dihydroguanine (8-oxoG) in mRNA, which can cause base mispairing during gene expression. Here we found that administration of 8-oxoGTP in MTH1-knockdown cells results in increased 8-oxoG content in mRNA. Under this condit...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Dai, Da-Peng, Gan, Wei, Hayakawa, Hiroshi, Zhu, Jia-Lou, Zhang, Xiu-Qing, Hu, Guo-Xin, Xu, Tao, Jiang, Zhe-Li, Zhang, Li-Qun, Hu, Xue-Da, Nie, Ben, Zhou, Yue, Li, Jin, Zhou, Xiao-Yang, Li, Jian, Zhang, Tie-Mei, He, Qing, Liu, Dong-Ge, Chen, Hai-Bo, Yang, Nan, Zuo, Ping-Ping, Zhang, Zhi-Xin, Yang, Huan-Ming, Wang, Yao, Wilson, Samuel H., Zeng, Yi-Xin, Wang, Jian-Ye, Sekiguchi, Mutsuo, Cai, Jian-Ping
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910836/
https://ncbi.nlm.nih.gov/pubmed/29610342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718363115
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