Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Stem cell fate can be influenced by metabolite levels in culture but it is unknown whether physiological variations in metabolite levels in normal tissues regulate stem cell function in vivo. We developed a metabolomics method for analysis of rare cell populations isolated directly from tissues and...

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Foilsithe in:Nature
Main Authors: Agathocleous, Michalis, Meacham, Corbin E., Burgess, Rebecca J., Piskounova, Elena, Zhao, Zhiyu, Crane, Genevieve M., Cowin, Brianna L., Bruner, Emily, Murphy, Malea M., Chen, Weina, Spangrude, Gerald J., Hu, Zeping, DeBerardinis, Ralph J., Morrison, Sean J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910063/
https://ncbi.nlm.nih.gov/pubmed/28825709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23876
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