Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Stem cell fate can be influenced by metabolite levels in culture but it is unknown whether physiological variations in metabolite levels in normal tissues regulate stem cell function in vivo. We developed a metabolomics method for analysis of rare cell populations isolated directly from tissues and...

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Publicado en:Nature
Autores principales: Agathocleous, Michalis, Meacham, Corbin E., Burgess, Rebecca J., Piskounova, Elena, Zhao, Zhiyu, Crane, Genevieve M., Cowin, Brianna L., Bruner, Emily, Murphy, Malea M., Chen, Weina, Spangrude, Gerald J., Hu, Zeping, DeBerardinis, Ralph J., Morrison, Sean J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910063/
https://ncbi.nlm.nih.gov/pubmed/28825709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23876
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