Collective Force Regulation in Anti-Parallel Microtubule Gliding by Dimeric Kif15 Kinesin Motors

During cell division, the mitotic kinesin-5 Eg5 generates most of the force required to separate centrosomes during spindle assembly. However, Kif15, another mitotic kinesin, can replace Eg5 function permitting mammalian cells to acquire resistance to Eg5 poisons. Unlike Eg5, the mechanism by which...

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Publicado en:Curr Biol
Main Authors: Reinemann, Dana N., Sturgill, Emma G., Das, Dibyendu Kumar, Degen, Miriam Steiner, Vörös, Zsuzsanna, Hwang, Wonmuk, Ohi, Ryoma, Lang, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909953/
https://ncbi.nlm.nih.gov/pubmed/28918951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.08.018
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