Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice

STUDY QUESTION: What is the impact of adenosine monophosphate-activated protein kinase (AMPK) activation on blastocyst formation, gene expression, and tight junction formation and function? SUMMARY ANSWER: AMPK activity must be tightly controlled for normal preimplantation development and blastocyst...

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Detalhes bibliográficos
Publicado no:Mol Hum Reprod
Main Authors: Calder, Michele D, Edwards, Nicole A, Betts, Dean H, Watson, Andrew J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909861/
https://ncbi.nlm.nih.gov/pubmed/28962017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gax050
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