Clinical implications of cancer gene mutations in patients with chronic lymphocytic leukemia treated with lenalidomide

Lenalidomide is clinically active in chronic lymphocytic leukemia (CLL), but its effectiveness in the context of the CLL mutational landscape is unknown. We performed targeted capture sequencing of 295 cancer genes in specimens from 102 CLL patients with treatment-naïve disease (TN patients) and 186...

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Pubblicato in:Blood
Autori principali: Takahashi, Koichi, Hu, Boyu, Wang, Feng, Yan, Yuanqing, Kim, Ekaterina, Vitale, Candida, Patel, Keyur P., Strati, Paolo, Gumbs, Curtis, Little, Latasha, Tippen, Samantha, Song, Xingzhi, Zhang, Jianhua, Jain, Nitin, Thompson, Philip, Garcia-Manero, Guillermo, Kantarjian, Hagop, Estrov, Zeev, Do, Kim-Anh, Keating, Michael, Burger, Jan A., Wierda, William G., Futreal, P. Andrew, Ferrajoli, Alessandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2018
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909764/
https://ncbi.nlm.nih.gov/pubmed/29358183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-11-817296
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