Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia–reperfusion

AIMS: Mitochondrial creatine kinase (MtCK) couples ATP production via oxidative phosphorylation to phosphocreatine in the cytosol, which acts as a mobile energy store available for regeneration of ATP at times of high demand. We hypothesized that elevating MtCK would be beneficial in ischaemia–reper...

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Détails bibliographiques
Publié dans:Cardiovasc Res
Auteurs principaux: Whittington, Hannah J, Ostrowski, Philip J, McAndrew, Debra J, Cao, Fang, Shaw, Andrew, Eykyn, Thomas R, Lake, Hannah A, Tyler, Jack, Schneider, Jurgen E, Neubauer, Stefan, Zervou, Sevasti, Lygate, Craig A
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909653/
https://ncbi.nlm.nih.gov/pubmed/29509881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy054
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