Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia–reperfusion

AIMS: Mitochondrial creatine kinase (MtCK) couples ATP production via oxidative phosphorylation to phosphocreatine in the cytosol, which acts as a mobile energy store available for regeneration of ATP at times of high demand. We hypothesized that elevating MtCK would be beneficial in ischaemia–reper...

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Vydáno v:Cardiovasc Res
Hlavní autoři: Whittington, Hannah J, Ostrowski, Philip J, McAndrew, Debra J, Cao, Fang, Shaw, Andrew, Eykyn, Thomas R, Lake, Hannah A, Tyler, Jack, Schneider, Jurgen E, Neubauer, Stefan, Zervou, Sevasti, Lygate, Craig A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909653/
https://ncbi.nlm.nih.gov/pubmed/29509881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy054
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