Acetylation and phosphorylation of human TFAM regulate TFAM–DNA interactions via contrasting mechanisms

Mitochondrial transcription factor A (TFAM) is essential for the maintenance, expression and transmission of mitochondrial DNA (mtDNA). However, mechanisms for the post-translational regulation of TFAM are poorly understood. Here, we show that TFAM is lysine acetylated within its high-mobility-group...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: King, Graeme A, Hashemi Shabestari, Maryam, Taris, Kees-Karel H, Pandey, Ashutosh K, Venkatesh, Sundararajan, Thilagavathi, Jayapalraja, Singh, Kamalendra, Krishna Koppisetti, Rama, Temiakov, Dmitry, Roos, Wouter H, Suzuki, Carolyn K, Wuite, Gijs J L
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909435/
https://ncbi.nlm.nih.gov/pubmed/29897602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky204
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