Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets

Variant surface antigens (VSAs) play a critical role in severe malaria pathogenesis. Defining gaps, or “lacunae”, in immunity to these Plasmodium falciparum antigens in children with severe malaria would improve our understanding of vulnerability to severe malaria and how protective immunity develop...

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Udgivet i:Sci Rep
Main Authors: Travassos, Mark A., Niangaly, Amadou, Bailey, Jason A., Ouattara, Amed, Coulibaly, Drissa, Lyke, Kirsten E., Laurens, Matthew B., Pablo, Jozelyn, Jasinskas, Algis, Nakajima, Rie, Berry, Andrea A., Adams, Matthew, Jacob, Christopher G., Pike, Andrew, Takala-Harrison, Shannon, Liang, Li, Kouriba, Bourema, Kone, Abdoulaye K., Rowe, J. Alexandra, Moulds, JoAnn, Diallo, Dapa A., Doumbo, Ogobara K., Thera, Mahamadou A., Felgner, Philip L., Plowe, Christopher V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908851/
https://ncbi.nlm.nih.gov/pubmed/29674705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24462-4
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