Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling

Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis that celecoxib activates AMP kinase (AMPK) signalling...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Al-Rashed, Fahad, Calay, Damien, Lang, Marie, Thornton, Clare C., Bauer, Andrea, Kiprianos, Allan, Haskard, Dorian O., Seneviratne, Anusha, Boyle, Joseph J., Schönthal, Alex H., Wheeler-Jones, Caroline P., Mason, Justin C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908847/
https://ncbi.nlm.nih.gov/pubmed/29674687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24548-z
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