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An orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) is a major side-effect of cancer treatment that significantly compromises quality of life of cancer patients and survivors. Identification of targets for pharmacological intervention to prevent or reverse CIPN is needed. We investigated Exchange prot...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Singhmar, Pooja, Huo, XiaoJiao, Li, Yan, Dougherty, Patrick M., Mei, Fang, Cheng, Xiaodong, Heijnen, Cobi J., Kavelaars, Annemieke
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908748/
https://ncbi.nlm.nih.gov/pubmed/29369966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001160
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