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Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status

Previously, we designed and synthesized a series of o-aminobenzamide-based histone deacetylase (HDAC) inhibitors, among which the representative compound 11a exhibited potent inhibitory activity against class I HDACs. In this study, we report the development of more potent hydrazide-based class I se...

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Vydáno v:J Med Chem
Hlavní autoři: Li, Xiaoyang, Peterson, Yuri K., Inks, Elizabeth S., Himes, Richard A., Li, Jiaying, Zhang, Yingjie, Kong, Xiujie, Chou, C. James
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908721/
https://ncbi.nlm.nih.gov/pubmed/29499113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00136
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