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Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells

Ferric chelates may be used as oral iron supplements or phosphate binders but both ferric citrate and ferric EDTA have been shown to promote tumor burden in murine models of colon cancer. Here we studied their effects on cancer cell growth, at typical supplemental iron levels encountered in the gast...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Scheers, Nathalie M., Pereira, Dora I.A., Faria, Nuno, Powell, Jonathan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908306/
https://ncbi.nlm.nih.gov/pubmed/29682205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24899
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