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Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer

Pemetrexed (PEM) improves the overall survival of patients with advanced non-small cell lung cancer (NSCLC) when administered as maintenance therapy. However, PEM resistance often appears during the therapy. Although thymidylate synthase is known to be responsible for PEM resistance, no other mechan...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tanino, Ryosuke, Tsubata, Yukari, Harashima, Nanae, Harada, Mamoru, Isobe, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908287/
https://ncbi.nlm.nih.gov/pubmed/29682186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24704
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