Efficient gene transfection to the brain with ultrasound irradiation in mice using stabilized bubble lipopolyplexes prepared by the surface charge regulation method

INTRODUCTION: We previously developed anionic ternary bubble lipopolyplexes, an ultrasound-responsive carrier, expecting safe and efficient gene transfection. However, bubble lipopolyplexes have a low capacity for echo gas (C(3)F(8)) encapsulation (EGE) in nonionic solution such as 5% glucose. On th...

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Detalles Bibliográficos
Publicado en:Int J Nanomedicine
Autores principales: Ogawa, Koki, Fuchigami, Yuki, Hagimori, Masayori, Fumoto, Shintaro, Miura, Yusuke, Kawakami, Shigeru
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2018
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907898/
https://ncbi.nlm.nih.gov/pubmed/29713163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S157375
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