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A CK2–RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR
Farnesoid X receptor (FXR) is a ligand-activated nuclear receptor that plays a central role in regulating genes involved in bile acid homeostasis, and fat and glucose metabolism. Here, we demonstrate a post-translational interplay between FXR phosphorylation, SUMOylation, and ubiquitination that dir...
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| Publicado no: | J Mol Cell Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5907841/ https://ncbi.nlm.nih.gov/pubmed/28201649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjx009 |
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