A CK2–RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR

Farnesoid X receptor (FXR) is a ligand-activated nuclear receptor that plays a central role in regulating genes involved in bile acid homeostasis, and fat and glucose metabolism. Here, we demonstrate a post-translational interplay between FXR phosphorylation, SUMOylation, and ubiquitination that dir...

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Detalles Bibliográficos
Publicado en:J Mol Cell Biol
Autores principales: Bilodeau, Stéphanie, Caron, Véronique, Gagnon, Jonathan, Kuftedjian, Alexandre, Tremblay, André
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907841/
https://ncbi.nlm.nih.gov/pubmed/28201649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjx009
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