Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in piggyBac Transposon-Engineered T Cells

Adoptive T cell therapy using chimeric antigen receptor (CAR)-modified T cells is a promising cancer immunotherapy. We previously developed a non-viral method of gene transfer into T cells using a piggyBac transposon system to improve the cost-effectiveness of CAR-T cell therapy. Here, we have furth...

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Publicado en:Mol Ther Methods Clin Dev
Autores principales: Morita, Daisuke, Nishio, Nobuhiro, Saito, Shoji, Tanaka, Miyuki, Kawashima, Nozomu, Okuno, Yusuke, Suzuki, Satoshi, Matsuda, Kazuyuki, Maeda, Yasuhiro, Wilson, Matthew H., Dotti, Gianpietro, Rooney, Cliona M., Takahashi, Yoshiyuki, Nakazawa, Yozo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907825/
https://ncbi.nlm.nih.gov/pubmed/29687032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.12.003
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