Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients

BACKGROUND: Thiazide and thiazide‐like diuretics are first‐line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with incompletely understood mechanisms. Our goal was to...

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Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Singh, Sonal, McDonough, Caitrin W., Gong, Yan, Alghamdi, Wael A., Arwood, Meghan J., Bargal, Salma A., Dumeny, Leanne, Li, Wen‐Yi, Mehanna, Mai, Stockard, Bradley, Yang, Guang, de Oliveira, Felipe A., Fredette, Natalie C., Shahin, Mohamed H., Bailey, Kent R., Beitelshees, Amber L., Boerwinkle, Eric, Chapman, Arlene B., Gums, John G., Turner, Stephen T., Cooper‐DeHoff, Rhonda M., Johnson, Julie A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907544/
https://ncbi.nlm.nih.gov/pubmed/29523524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007339
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