Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

Leukocyte-released antimicrobial peptides contribute to pathogen elimination and activation of the immune system. Their role in thrombosis is incompletely understood. Here we show that the cathelicidin LL-37 is abundant in thrombi from patients with acute myocardial infarction. Its mouse homologue,...

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Vydáno v:Nat Commun
Hlavní autoři: Pircher, Joachim, Czermak, Thomas, Ehrlich, Andreas, Eberle, Clemens, Gaitzsch, Erik, Margraf, Andreas, Grommes, Jochen, Saha, Prakash, Titova, Anna, Ishikawa-Ankerhold, Hellen, Stark, Konstantin, Petzold, Tobias, Stocker, Thomas, Weckbach, Ludwig T, Novotny, Julia, Sperandio, Markus, Nieswandt, Bernhard, Smith, Alberto, Mannell, Hanna, Walzog, Barbara, Horst, David, Soehnlein, Oliver, Massberg, Steffen, Schulz, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906636/
https://ncbi.nlm.nih.gov/pubmed/29670076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03925-2
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