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Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention

ABSTRACT: In this contribution, we report synthetic strategies towards potential ligands for the study of binding differences between PhzE, the first enzyme in the biosynthesis of phenazines, and the related enzyme anthranilate synthase. The ligands were designed with the overriding goal to develop...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Monatsh Chem
Hauptverfasser: Guttenberger, Nikolaus, Schlatzer, Thomas, Leypold, Mario, Tassoti, Sebastian, Breinbauer, Rolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Vienna 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906492/
https://ncbi.nlm.nih.gov/pubmed/29681660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-017-2100-z
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