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Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention

ABSTRACT: In this contribution, we report synthetic strategies towards potential ligands for the study of binding differences between PhzE, the first enzyme in the biosynthesis of phenazines, and the related enzyme anthranilate synthase. The ligands were designed with the overriding goal to develop...

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Vydáno v:Monatsh Chem
Hlavní autoři: Guttenberger, Nikolaus, Schlatzer, Thomas, Leypold, Mario, Tassoti, Sebastian, Breinbauer, Rolf
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Vienna 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906492/
https://ncbi.nlm.nih.gov/pubmed/29681660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-017-2100-z
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