Upregulation of neuronal astrocyte elevated gene-1 protects nigral dopaminergic neurons in vivo

The role of astrocyte elevated gene-1 (AEG-1) in nigral dopaminergic (DA) neurons has not been studied. Here we report that the expression of AEG-1 was significantly lower in DA neurons in the postmortem substantia nigra of patients with Parkinson’s disease (PD) compared to age-matched controls. Sim...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Leem, Eunju, Kim, Hyung-Jun, Choi, Minji, Kim, Sehwan, Oh, Yong-Seok, Lee, Kea Joo, Choe, Young-Shik, Um, Jae-Young, Shin, Won-Ho, Jeong, Jae Yeong, Jin, Byung Kwan, Kim, Dong Woon, McLean, Catriona, Fisher, Paul B., Kholodilov, Nikolai, Ahn, Kwang Seok, Lee, Jae Man, Jung, Un Ju, Lee, Seok-Geun, Kim, Sang Ryong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906475/
https://ncbi.nlm.nih.gov/pubmed/29670079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0491-3
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