X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE

The Radical SAM (RS) enzyme PqqE catalyzes the first step in the biosynthesis of the bacterial cofactor pyrroloquinoline quinone, forming a new carbon-carbon bond between two sidechains within the ribosomally synthesized peptide substrate PqqA. In addition to the active site RS 4Fe-4S cluster, PqqE...

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Publicado no:Biochemistry
Main Authors: Barr, Ian, Stich, Troy A., Gizzi, Anthony, Grove, Tyler, Bonanno, Jeffrey B., Latham, John A., Chung, Tyler, Wilmot, Carrie M., Britt, R. David, Almo, Steven C., Klinman, Judith P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905707/
https://ncbi.nlm.nih.gov/pubmed/29405700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01097
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