Suppression of the ERK–SRF axis facilitates somatic cell reprogramming

The molecular mechanism underlying the initiation of somatic cell reprogramming into induced pluripotent stem cells (iPSCs) has not been well described. Thus, we generated single-cell-derived clones by using a combination of drug-inducible vectors encoding transcription factors (Oct4, Sox2, Klf4 and...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Huh, Sejong, Song, Hwa-Ryung, Jeong, Geuk-Rae, Jang, Hyejin, Seo, Nan-Hee, Lee, Ju-Hyun, Yi, Ji-Yeun, Lee, Byongsun, Choi, Hyun Woo, Do, Jeong Tae, Kim, Jin-Su, Lee, Soo-Hong, Jung, Jae-Won, Lee, Taekyu, Shim, Jaekyung, Han, Myung-Kwan, Lee, Tae-Hee
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903827/
https://ncbi.nlm.nih.gov/pubmed/29472703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.279
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