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Angiotensin II Type 1 Receptor Agonistic Autoantibody Blockade Prevents Preeclamptic Symptoms in Placental Ischemic Rats
Women with preeclampsia (PE) produce agonistic autoantibodies to the Angiotensin II type 1 receptor (AT1-AA), which stimulate reactive oxygen species (ROS), inflammatory factors, and hypertensive mechanisms (Endothelin and sFlt-1) in rodent models of PE. The placental ischemic reduced uterine perfus...
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| Veröffentlicht in: | Hypertension |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5903585/ https://ncbi.nlm.nih.gov/pubmed/29555668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10681 |
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