An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

Transient receptor potential canonical (TRPC) channels TRPC3, TRPC6 and TRPC7 are able to sense the lipid messenger diacylglycerol (DAG). The DAG-sensing and lipid-gating processes in these ion channels are still unknown. To gain insights into the lipid-sensing principle, we generated a DAG photoswi...

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Pubblicato in:Nat Chem Biol
Autori principali: Lichtenegger, Michaela, Tiapko, Oleksandra, Svobodova, Barbora, Stockner, Thomas, Glasnov, Toma N., Schreibmayer, Wolfgang, Platzer, Dieter, de la Cruz, Gema Guedes, Krenn, Sarah, Schober, Romana, Shrestha, Niroj, Schindl, Rainer, Romanin, Christoph, Groschner, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903546/
https://ncbi.nlm.nih.gov/pubmed/29556099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0015-6
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