The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool

AIM: This research aims to evaluate the predictive performance of a published allopurinol dosing tool. METHODS: Allopurinol dose predictions were compared to the actual dose required to achieve serum urate (SU) <0.36 mmol l(−1) using mean prediction error. The influence of patient factors on dose...

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Publicado en:Br J Clin Pharmacol
Autores principales: Wright, Daniel F. B., Dalbeth, Nicola, Phipps‐Green, Amanda J., Merriman, Tony R., Barclay, Murray L., Drake, Jill, Tan, Paul, Horne, Anne, Stamp, Lisa K.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Pharmacokinetic Dynamic Relationships
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903228/
https://ncbi.nlm.nih.gov/pubmed/29341237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13516
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