PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT

Glioblastoma multiforme (GBM) is the most malignant brain tumor and is associated with poor prognosis due to its thorny localization, lack of efficacious therapies and complex biology. Among the numerous pathways driving GBM biology studied so far, PTEN/phosphatidylinositol-4,5-bisphosphate 3-kinase...

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Detalles Bibliográficos
Publicado en:Front Cell Neurosci
Autores principales: Mecca, Carmen, Giambanco, Ileana, Bruscoli, Stefano, Bereshchenko, Oxana, Fioretti, Bernard, Riccardi, Carlo, Donato, Rosario, Arcuri, Cataldo
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902688/
https://ncbi.nlm.nih.gov/pubmed/29692710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00099
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