β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination

The molecular mechanisms underlying resistance to radiotherapy in breast cancer cells remain elusive. Previously, we reported that elevated β1-integrin is associated with enhanced breast cancer cell survival postirradiation, but how β1-integrin conferred radioresistance was unclear. Ionizing radiati...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Ahmed, Kazi Mokim, Pandita, Raj K., Singh, Dharmendra Kumar, Hunt, Clayton R., Pandita, Tej K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902589/
https://ncbi.nlm.nih.gov/pubmed/29463647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00672-17
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