ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells

4-Methoxy-TEMPO, a derivative of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), is a stable nitroxide radical and is generally used in organic and pharmaceutical syntheses for the oxidation of alcohols. Previously, we reported the involvement of reactive oxygen species (ROS) and c-Jun N-terminal kina...

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Bibliographische Detailangaben
Veröffentlicht in:Arch Toxicol
Hauptverfasser: Zhang, Zhuhong, Ren, Zhen, Chen, Si, Guo, Xiaoqing, Liu, Fang, Guo, Lei, Mei, Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901683/
https://ncbi.nlm.nih.gov/pubmed/28993908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2084-9
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