Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids

Several variants of a nucleic acid binding motif (RRM1) of putative transcription factor hnRNP LL containing nucleobase amino acids at specific positions have been prepared and used to study binding affinity for the BCL2 i-motif DNA. Molecular modeling suggested a number of amino acids in RRM1 likel...

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Publicado en:J Am Chem Soc
Main Authors: Bai, Xiaoguang, Talukder, Poulami, Daskalova, Sasha M., Roy, Basab, Chen, Shengxi, Li, Zhongxian, Dedkova, Larisa M., Hecht, Sidney M.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901667/
https://ncbi.nlm.nih.gov/pubmed/28263595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11825
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