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Alteration of Transcriptional Regulator Rob In Vivo: Enhancement of Promoter DNA Binding and Antibiotic Resistance in the Presence of Nucleobase Amino Acids

The identification of proteins that bind selectively to nucleic acid sequences is an ongoing challenge. We previously synthesized nucleobase amino acids designed to replace proteinogenic amino acids; these were incorporated into proteins to bind specific nucleic acids predictably. An early example i...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Zhang, Chao, Chen, Shengxi, Bai, Xiaoguang, Dedkova, Larisa M., Hecht, Sidney M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175798/
https://ncbi.nlm.nih.gov/pubmed/32157864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00103
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