LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells

The fourth member of the leucine-rich repeat–containing GPCR family (LGR4, frequently referred to as GPR48) and its cognate ligands, R-spondins (RSPOs) play crucial roles in the development of multiple organs as well as the survival of adult stem cells by activation of canonical Wnt signaling. Wnt/β...

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Bibliographic Details
Published in:FASEB J
Main Authors: Yue, Zhiying, Yuan, Zengjin, Zeng, Li, Wang, Ying, Lai, Li, Li, Jing, Sun, Peng, Xue, Xiwen, Qi, Junyi, Yang, Zhengfeng, Zheng, Yansen, Fang, Yuanzhang, Li, Dali, Siwko, Stefan, Li, Yi, Luo, Jian, Liu, Mingyao
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2018
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901378/
https://ncbi.nlm.nih.gov/pubmed/29269400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700897R
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