Amidate Prodrugs of Cyclic 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity

[Image: see text] A series of amidate prodrugs of cyclic 9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (cHPMPA) featuring different amino acid motifs were synthesized. All phosphonamidates derived from (S)-cHPMPA displayed a broad spectrum activity against herpesviruses with EC(50) values in the l...

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Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Luo, Min, Groaz, Elisabetta, De Jonghe, Steven, Snoeck, Robert, Andrei, Graciela, Herdewijn, Piet
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2018
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900341/
https://ncbi.nlm.nih.gov/pubmed/29670705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00079
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