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Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1)

[Image: see text] The anticancer effect of manumycin A (Man A) has been attributed to the inhibition of farnesyl transferase (FTase), an enzyme that is responsible for post-translational modification of Ras proteins. However, we have discovered that Man A inhibits mammalian cytosolic thioredoxin red...

詳細記述

保存先:
書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Tuladhar, Anupama, Rein, Kathleen S.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2018
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900327/
https://ncbi.nlm.nih.gov/pubmed/29670693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00489
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