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Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1)
[Image: see text] The anticancer effect of manumycin A (Man A) has been attributed to the inhibition of farnesyl transferase (FTase), an enzyme that is responsible for post-translational modification of Ras proteins. However, we have discovered that Man A inhibits mammalian cytosolic thioredoxin red...
保存先:
| 出版年: | ACS Med Chem Lett |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2018
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5900327/ https://ncbi.nlm.nih.gov/pubmed/29670693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00489 |
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