Rlip depletion prevents spontaneous neoplasia in TP53 null mice

TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53(−/−)) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma. RALBP1 (RLIP76, Rlip) is a stress-protective, mercapturic acid pathway transporter protein that also...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Awasthi, Sanjay, Tompkins, Joshua, Singhal, Jyotsana, Riggs, Arthur D., Yadav, Sushma, Wu, Xiwei, Singh, Sharda, Warden, Charles, Liu, Zheng, Wang, Jinhui, Slavin, Thomas P., Weitzel, Jeffrey N., Yuan, Yate-Ching, Awasthi, Meenakshi, Srivastava, Satish K., Awasthi, Yogesh C., Singhal, Sharad S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899455/
https://ncbi.nlm.nih.gov/pubmed/29572430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719586115
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