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Sign epistasis caused by hierarchy within signalling cascades
Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in Escherichia coli. We show that sign epistasis arises from the benefi...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899173/ https://ncbi.nlm.nih.gov/pubmed/29654280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03644-8 |
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