Biological Studies and Target Engagement of the 2-C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1R,3S)-MMV008138 and Analogs

Malaria continues to be one of the deadliest diseases worldwide, and the emergence of drug resistance parasites is a constant threat. Plasmodium parasites utilize the methylerythritol phosphate (MEP) pathway to synthesize isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which...

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Publicado en:ACS Infect Dis
Autores principales: Ghavami, Maryam, Merino, Emilio F., Yao, Zhong-Ke, Elahi, Rubayet, Simpson, Morgan E., Fernández-Murga, Maria L., Butler, Joshua H., Casasanta, Michael A., Krai, Priscilla M., Totrov, Maxim M., Slade, Daniel J., Carlier, Paul R., Cassera, Maria Belen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899049/
https://ncbi.nlm.nih.gov/pubmed/29072835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00159
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