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Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We use transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5898828/ https://ncbi.nlm.nih.gov/pubmed/29439242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad6469 |
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