Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

Prokaryotes acquire virus resistance by integrating short fragments of viral nucleic acid into clusters of regularly interspaced short palindromic repeats (CRISPRs). Here we show how virus-derived sequences contained in CRISPRs are used by CRISPR-associated (Cas) proteins from the host to mediate an...

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Udgivet i:Science
Main Authors: Brouns, Stan J. J., Jore, Matthijs M., Lundgren, Magnus, Westra, Edze R., Slijkhuis, Rik J. H., Snijders, Ambrosius P. L., Dickman, Mark J., Makarova, Kira S., Koonin, Eugene V., van der Oost, John
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898235/
https://ncbi.nlm.nih.gov/pubmed/18703739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1159689
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