Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

Prokaryotes acquire virus resistance by integrating short fragments of viral nucleic acid into clusters of regularly interspaced short palindromic repeats (CRISPRs). Here we show how virus-derived sequences contained in CRISPRs are used by CRISPR-associated (Cas) proteins from the host to mediate an...

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Publié dans:Science
Auteurs principaux: Brouns, Stan J. J., Jore, Matthijs M., Lundgren, Magnus, Westra, Edze R., Slijkhuis, Rik J. H., Snijders, Ambrosius P. L., Dickman, Mark J., Makarova, Kira S., Koonin, Eugene V., van der Oost, John
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898235/
https://ncbi.nlm.nih.gov/pubmed/18703739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1159689
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