BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway

BACKGROUND: Mammary cancer is highly prevalent in dogs and cats and results in a poor prognosis due to critically lacking viable treatment options. Recent human and mouse studies have suggested that inhibiting peptidyl arginine deiminase enzymes (PAD) may be a novel breast cancer therapy. Based on t...

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Publicado en:BMC Cancer
Autores principales: Ledet, Melissa M., Anderson, Robyn, Harman, Rebecca, Muth, Aaron, Thompson, Paul R., Coonrod, Scott A., Van de Walle, Gerlinde R.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898062/
https://ncbi.nlm.nih.gov/pubmed/29649984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4323-8
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