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Brain Iron Distribution after Multiple Doses of Ultra-small Superparamagnetic Iron Oxide Particles in Rats

The purpose of this study is to determine the effects of high cumulative doses of ultra-small paramagnetic iron oxide (USPIO) used in neuroimaging studies. We intravenously administered 8 mg/kg of 2 USPIO compounds daily for 4 wk to male Sprague–Dawley rats (Crl:SD). Multiecho gradient-echo MRI, ser...

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Detalhes bibliográficos
Publicado no:Comp Med
Main Authors: Gorman, Andrew W, Deh, Kofi M, Schwiedrzik, Caspar M, White, Julie R, Groman, Ernest Victor, Fisher, Clark A, Gillen, Kelly M, Spincemaille, Pascal, Rasmussen, Skye, Prince, Martin R, Voss, Henning U, Freiwald, Winrich A, Wang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Laboratory Animal Science 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897970/
https://ncbi.nlm.nih.gov/pubmed/29663939
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