Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins....

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Bibliographic Details
Published in:Chem Sci
Main Authors: Dandela, Rambabu, Mantin, Danielle, Cravatt, Benjamin F., Rayo, Josep, Meijler, Michael M.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897874/
https://ncbi.nlm.nih.gov/pubmed/29719702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc04287f
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